High-grade uroepithelial carcinoma is poorly differentiated uroepithelial carcinoma, and the most common type of uroepithelial carcinoma is bladder cancer. For high-grade uroepithelial carcinoma, in principle, it is recommended to perform total cystectomy, and partial cystectomy can also be performed selectively. For high-grade uroepithelial cancer is prone to recurrence in the bladder, and it has a characteristic, multi-source and multi-center, which can recur in other parts of the bladder possibly. Removal of the entire bladder and prostate in this case can play a very good prognostic role. After surgery, chemotherapy with GC protocol can be performed if necessary, which can effectively prolong the survival time of the patient.