There is no fourth generation of NSAIDs. NSAIDs include salicylic acid, anilines, indoles, arylacetic acid, arylpropionic acid, enolic acid, alkanones, isobufenac, selective COX-2 inhibitors, etc. Commonly used are aspirin, indomethacin, diclofenac, ibuprofen, meloxicam, celecoxib, and so on. Non-steroidal anti-inflammatory drugs have antipyretic and analgesic effects. The common ones are salicylic acid such as aspirin, aniline such as acetaminophen, indole such as indomethacin, arylacetic acid such as diclofenac, arylpropionic acid such as ibuprofen, enolacetic acid such as meloxicam, alkanes and ketones such as nabumetone, isobutylphenic acid such as sulforaphane, and selective COX-2 inhibitors such as celecoxib. Common adverse reactions include gastrointestinal symptoms such as epigastric pain, nausea and vomiting, cardiovascular thrombotic events, allergic reactions such as rash and pruritus, and hepatic impairment. It is contraindicated in patients who are allergic to the product, asthma induced by taking non-steroidal anti-inflammatory drugs as well as urticaria or anaphylactic reactions, coronary artery bypass grafting surgery, active peptic ulcer bleeding and other patients. Pay attention to observe whether there are adverse reactions such as gastrointestinal bleeding during the use of the drug, and minimize the duration of use and dosage. Patients using NSAIDs are advised to use them under medical supervision and not privately.