There is no clinical statement on how tacrolimus and fluticasone propionate work well together. It is recommended that tacrolimus and fluticasone propionate be used separately to avoid increasing the emergence of side effects such as infection and abnormal kidney function. Tacrolimus can be used for the prevention of graft rejection after liver and kidney transplantation, etc. It can also be used in patients with spring keratoconjunctivitis in whom antiallergic treatment is not effective. It is contraindicated in women who are allergic to any of the components of the product, allergic to other macrolides and during pregnancy. Fluticasone propionate is used in adults for a variety of inflammatory and pruritic dermatoses relieved by corticosteroids, for the prevention and treatment of seasonal allergic rhinitis and perennial allergic rhinitis. Discomfort such as skin infections, infected eczema, finger paresthesias and dry skin may occur with use. It is contraindicated in rosacea, acne vulgaris, rosacea and infants under 1 year of age. Although the Tacrolimus and Fluticasone Propionate drug inserts do not indicate that there is an interaction between the two drugs, it is recommended that Tacrolimus and Fluticasone Propionate be used separately for better results as both Tacrolimus and Fluticasone Propionate are known to aggravate infections, abnormal kidney function and other side effects. Tacrolimus and fluticasone propionate must be used under the supervision of a doctor.