High serum total bilirubin can be categorized as either predominantly high indirect bilirubin or predominantly high direct bilirubin. Different cases are caused by different etiologic factors and need to be examined in the hospital for clarification. 1. Elevated serum total bilirubin, mainly indirect bilirubin, indicates that the liver cells are damaged, unable to convert indirect bilirubin into direct bilirubin, resulting in high direct bilirubin and total bilirubin belongs to hepatocellular jaundice, which may be caused by viral hepatitis, fatty liver disease, etc. Or may be caused by hemolysis, bilirubin, or other factors, which may lead to jaundice. It may be caused by viral hepatitis, fatty liver and other factors. Or it may be caused by hemolysis, which increases the source of bilirubin and causes the elevation of indirect bilirubin. 2. Elevated total serum bilirubin, mainly direct bilirubin, indicates that the discharge of bilirubin is impaired at this time, which may be caused by cholecystitis, bile duct obstruction and other factors. The specific cause of the disease needs to be clarified after examination in the hospital, and then for treatment, do not take drugs without authorization.