Low to medium differentiated adenocarcinoma is a malignant tumor of the glandular epithelium, commonly found in the breast, lung, digestive system, prostate pancreas, etc. The presence of a medium to low differentiated adenocarcinoma indicates that the morphology of the cancer cells at this time is adenocarcinoma with a moderate to low degree of differentiation. The degree of differentiation of cancer can be divided into highly differentiated cancer, moderately differentiated cancer, low differentiated cancer and undifferentiated cancer. The malignancy of cancer tissues at this time is higher compared to highly differentiated cancer, and the tissue maturity is poorer and more heterogeneous. Especially in the case of hypodifferentiated adenocarcinoma and glandular ducts, the malignant degree is higher and the prognosis for treatment is poorer, and spread and metastasis usually occur in the early stage. The higher the malignancy of the cancer cells, the higher the chance of recurrence and the faster the growth, spread and metastasis of the cancer. For middle and low differentiated adenocarcinoma, if detected at early stage, the treatment effect is better, such as radical surgery to remove the primary lesion and completely remove the cancer cells in the body, the patient’s 10-year survival rate can be greatly increased. For patients in the middle and late stages, as lymph nodes and distant metastases have already appeared, treatment is more difficult and not completely curable, and patients have a lower chance of survival. Therefore, for cancer, early detection, early diagnosis and early treatment are important measures to treat cancer and even cure it. When diagnosed with middle and low differentiated adenocarcinoma, the first treatment should be surgical resection, and post-operative treatment should be combined with radiation therapy, chemotherapy and targeted drug therapy to strictly control the progress of the disease.