The time to develop cancer in moderate intestinal metaplasia is generally indeterminable and is influenced by a number of factors such as the actual type of disease, treatment, and care measures of the patient. Intestinal epithelial metaplasia is a tissue type in which the epithelium in the stomach, esophagus, and other digestive system tissues is converted to resemble the intestinal mucosal epithelium. It is characterized by the appearance of markers that resemble cup cells and enterocytes. Intestinal chemosis can be classified according to grade as mild, moderate, or severe. The higher the grade of intestinal chemosis, the higher the patient’s risk of developing cancer increases accordingly. The regular and proper treatment plays an important role in controlling the deterioration of the disease and reducing the probability of cancer. Chronic inflammatory diseases are common causes of intestinal metaplasia, such as chronic atrophic gastritis, reflux esophagitis and Helicobacter pylori infection. Therefore, patients with such conditions should be promptly diagnosed with specific types of sensitive bacteria through pathological analysis, and then select targeted antimicrobials and other drugs for comprehensive treatment. In addition, good living and eating habits can also play a supporting role in the treatment, such as regular and quantitative meals, light diet, avoiding too acidic, too hard, spicy and other types of food.