Three plus signs for routine urine glucose means that there is just a lot of glucose being excreted in the urine. This condition indicates that there is sugar that is filtered through the glomerulus and poured into the urine and then excreted out of the body, consider diabetes. If diabetes is diagnosed, three plus signs of urine glucose indicates poor blood sugar control. If diabetes is prolonged and not effectively treated, it can lead to diabetic nephropathy. This is when the permeability of the glomerulus increases, and three plus signs of glucose in the urine will occur. In this case, it is recommended that you should go to the endocrinology department for further examination and effective control of diabetic blood glucose.