1.Phlebitis may occur after chemotherapy for cholangiocarcinoma. Many antitumor drugs such as nitrogen mustard, vincristine and vincristine have strong local irritation, which may cause tissue necrosis or even long-lasting if injected subcutaneously due to careless operation. In the process of use, patients should be well explained to eliminate the nervousness and introduce the nature of drugs, toxic and side-effects, so that patients can have an idea in advance and prevent adverse consequences due to patients’ strong tolerance or reluctance to tolerate pain and not reporting to medical personnel. 2.Gastrointestinal reactions may occur after chemotherapy for bile duct cancer Most antitumor drugs have damaging effects on the mucous membrane of gastrointestinal tract, which often manifest as gastrointestinal reactions such as loss of appetite, nausea, vomiting and diarrhea. For example, fluorouracil and methotrexate can cause frequent diarrhea and even blood in the stool. Most patients have heavy reactions in the first dose, which will be gradually reduced later. In the process of applying anti-cancer drugs, patients should be concerned about their eating condition and be given a light diet with easy digestion and less fat. For patients with heavy reactions to drugs, it is advisable to arrange to administer drugs before bedtime or after meals so as not to interfere with eating. Those who have severe vomiting should eat less and eat more, and rehydrate when necessary.