GreyTurner syndrome is a clinical sign of purple petechiae in the lumbar region, etc., in patients with severe necrotizing pancreatitis. When severe necrotizing pancreatitis occurs, pancreatic tissue is digested and absorbed by pancreatic enzymes, resulting in a large amount of pancreatic enzymes being released into the blood and surrounding tissues, and some of the pancreatic enzymes pass through the muscle layer along the retroperitoneum to the subcutaneous tissues, causing capillary hemorrhage, which can lead to blue-green-brown irregular bruises on the skin of the lumbar region bilaterally or unilaterally and is known as the GreyTurner sign clinically. The appearance of GreyTurner’s sign, the general surface may be suffering from severe acute pancreatitis (acute hemorrhagic necrotizing pancreatitis), pancreatic trauma, retroperitoneal hematoma three conditions, the diagnosis is not difficult. It indicates that the condition is serious and the prognosis is poor, and timely medical treatment should be sought. When the diagnosis of severe necrotizing pancreatitis is confirmed, it is necessary to stay in the monitoring ward immediately, fasting, gastrointestinal decompression, inhibiting pancreatic fluid secretion, preventing infections and nutritional support, and hemodialysis treatment may be required. To inhibit the secretion of pancreatic fluid, growth inhibitors, octreotide, ustekin and other drugs can be applied; to prevent infection, strong antibiotics such as ceftriaxone sodium and moxifloxacin are commonly used.