Cold remedies and painkillers are not recommended to be taken together. Cold remedies are usually compounded medications, with both Chinese and Western medicines. In particular, western medicines will contain drugs with analgesic and antipyretic properties, such as ibuprofen and acetaminophen. These drugs are mainly metabolized by the liver, and some patients will also cause gastrointestinal tract irritation after taking them, such as causing abdominal pain, abdominal distension, and even nausea, vomiting adverse reactions. Painkillers are also a class of antipyretic and analgesic drugs, which are still metabolized by the liver and are also irritating to the gastrointestinal tract. If these two types of drugs at the same time, will increase the metabolic burden on the liver, and will cause the gastrointestinal tract stimulation is more obvious, so can not be taken at the same time.