Pain in the middle of the rib cage after deep inspiration can be caused by many reasons. 1, most commonly due to soft tissue injury of the chest wall caused by trauma, usually with a clear history of trauma (e.g., external punch, fall, etc.); 2, secondly, seen in pneumothorax, commonly in the elderly, due to improper posture or exertion leading to spontaneous rupture of the pleura; 3, inflammatory reactions in the lungs such as bronchitis or pleural inflammation secondary to pneumonia, can also lead to pain associated with respiratory motion-related chest wall pain; 4, such as herpes virus infection and costochondritis, which can also lead to chest wall pain. Once the pain in the middle of the rib cage occurs after deep inspiration and does not relieve itself within a short period of time, it is recommended to seek professional help at the hospital.