Patients with SLE may experience joint pain, muscle pain and other painful sensations. Systemic lupus erythematosus is a connective tissue disease mainly mediated by autoimmunity. The disease can invade multiple organs and systems, and the symptoms are more complicated. In the early stage of the disease, it only invades 1~2 systems, and in the later stage, it can be manifested as alternating remission and aggravation of the disease, with common symptoms such as pteronyssinus erythematosus on the face, ulceration of mucous membranes, alopecia, fever, muscular pain, malaise, and joint pains, and so on. When SLE involves the pancreas, intestines and exocrine glands, it can also lead to abdominal pain, parotid gland swelling and pain, musculoskeletal joint pain, vomiting, abdominal distension, etc. Effective and timely treatment can alleviate the symptoms of the patients and control the progress of the disease. SLE patients can go to the Department of Rheumatology and Immunology of regular hospitals for detailed consultation.