Rotundine can be applied to patients with anxiety and headache. For patients with insomnia alone, treatment with Rotundine alone is not effective. Patients with insomnia often have difficulty falling asleep, maintaining sleep, waking easily, waking early, or falling back asleep. For these patients, the first treatment must remove the patient’s causative factors, such as the presence of mental stress, heavy thought burden or sleep environment is not very good, more noisy, or the presence of light stimulation, the patient may have insomnia. The first thing is to maintain a good sleep environment. Patients who still have insomnia in a good sleep environment can be treated by applying drugs that improve sleep.