The maximum daily dose of mannitol is 4 bottles of 250ml, which is 1000ml. The dosage and usage of mannitol should be decided according to the course of the disease and the condition. For hypertension, 125 ml of mannitol can be applied if it is needed for temporary relief of high blood pressure. For acute cervical spondylosis and lumbar disc herniation, 250 ml of mannitol can be administered once/day to relieve edema and compression. For acute hypertension, hypertensive encephalopathy and hypertensive crisis, 250ml of mannitol can be given twice/day, which means that the maximum daily dosage can be up to 500ml, but for hemorrhagic cerebral infarction, acute cerebral edema compressing the nerve center and even causing brain herniation, 250ml can be given 4 times/day, which means that the maximum daily dosage is within 1000ml. This is normal.