Not only is it very dangerous and easy to injure brain tissue or even directly endanger life due to external impact or bump, but the cranial defect also causes rapid changes in intracranial environment, unstable intracranial pressure, disturbance of cerebral blood circulation and blood circulation, and the normal function of brain nerve is affected, resulting in a series of cranial defect syndrome. Moreover, this will also cause great damage to the patient’s psychology, and the patient will easily have low self-esteem and depression. Therefore, cranial defects need to be repaired in a timely manner. There are many reasons for skull defects, such as traffic accidents, production safety accidents, falling objects, fights and so on, which may cause serious cranial injuries and damage to the skull, and finally form skull defects. In fact, another important reason is that some craniotomy may leave skull defects after surgery. If a skull defect is caused by a craniotomy, it is recommended that a skull repair should be performed in a timely manner. However, not all craniotomies result in cranial defects, because some craniotomies return the cranial bone flap to the original bone window immediately after the surgery, so that the cranial defect is not caused. Most of the craniotomies that result in cranial defects are due to high intracranial pressure, and the flap cannot be returned to the original bone window immediately, thus leaving a cranial defect that requires later cranial repair. At present, we use new polyether ether ketone peek material, and constantly carry out technical innovation and upgrade and material optimization design, and also innovatively introduce the concept of cosmetic plastic surgery, so as to carry out comprehensive peek cranial repair plastic surgery, which can achieve anatomical integrity, perfect function and beautiful appearance, which is well recognized by the majority of patients with cranial defects and their families.