The deterioration of the condition of heart failure patients include: severe dyspnea, large amount of intracavitary fluid, severe edema, mental symptoms and so on. 1. Severe dyspnea: most of the patients with end-stage heart failure will be combined with progressive respiratory failure, and the patients will have severe dyspnea, such as deep and fast respiration, irregular rhythm, cyanosis and so on. 2. Large amount of intracavitary fluid: severe venous stasis in heart failure will promote fluid exudation, forming large amount of pleural fluid and ascites, and the patient will have dyspnea, abdominal distension, thoracic dilatation and other manifestations. 3. Severe edema: severe venous stasis will promote the generation of tissue fluid, and a large amount of fluid accumulates in the tissue space causing severe generalized edema, especially the lower limbs are more obvious. 4. Mental symptoms: hypoxia, brain tissue edema and other factors will cause a series of mental symptoms, such as apathy, dizziness, headache, confusion, drowsiness, coma until death. It is recommended to consult a doctor as soon as possible to avoid delaying the condition.