Men can develop systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is one of the most common diseases in rheumatology. It is an autoimmune disease characterized by the formation of disease-causing autoantibodies and immune complexes that mediate organ and tissue damage. Although SLE is most common in women of childbearing age, men can also develop SLE, with a relatively small number of female patients. The specific condition of SLE is not yet clear, and may be related to estrogen, medication, sunlight and genetic factors. Both male and female patients diagnosed with SLE should receive timely and standardized therapeutic medications such as glucocorticosteroids such as prednisone and immunomodulatory drugs such as hydroxychloroquine, in order to control the progression of the disease as early as possible and to prevent and minimize the disease from recurring. SLE patients can go to the Department of Rheumatology and Immunology of regular hospitals for detailed consultation and standardized treatment as prescribed by doctors.