Stabbing pain in the urethra is a type of urinary pain, mostly caused by diseases of the urinary system or the reproductive system. It may be accompanied by other symptoms, including urinary urgency and frequency, and in severe cases, generalized fever may occur. Intraurethral stabbing pain can occur at different times of urination or persist on a daily basis. Common causes and treatments include: 1. Inflammation: Inflammation of the urinary system stimulates the mucous membrane inside the urethra and can produce painful sensations. Common inflammatory conditions include acute and chronic cystitis, pyelonephritis and prostatitis, which are usually accompanied by symptoms such as urinary frequency, urinary urgency and even fever. Chronic prostatitis can also lead to difficulty in urination, dripping urine, thin urine stream, etc. due to enlargement of the prostate gland; 2. Stones: urinary stones can stimulate the mucous membrane of the urethra and produce symptoms such as painful urination, kidney stones, ureteral stones can show symptoms such as lumbar pain, renal colic, percussion pain in the kidney area, etc. Bladder stones can show sudden interruption of urination and can continue to urinate after changing position; 3. Tumors: the cause is similar to stones, mostly seen in Bladder cancer, prostate cancer, urethra cancer and other diseases, cancer in other parts metastasized to the urinary system may also cause stabbing pain symptoms in the urethra. Treatment: 1. Drug treatment: According to the patient’s condition and the causative bacteria, effective antibiotics can be selected for anti-infection treatment. Commonly used drugs include minocycline hydrochloride, doxycycline hydrochloride, levofloxacin, ceftazidime, piperacillin, etc. If necessary, analgesics such as ibuprofen and acetaminophen can be given to relieve pain; 2. Surgery: stones can be treated by extracorporeal lithotripsy or endoscopic lithotripsy, and tumors are usually treated by surgery, divided into cystoscopic surgery and traditional open surgery, which need to be selected according to the size of the patient’s stones and tumors.