“It’s time to have a second baby!” With the opening of the national policy and the arrival of the “two-child era”, more and more one-child families are engaged in the state of “preparing” for the second child. After the age of 35, women’s body functions are obviously in a downward trend, so if you have already entered the ranks of advanced maternal age, how can we make our pregnancy preparation more scientific and effective? Here we will talk about the scientific preparation for pregnancy for older couples. Scientific preparation for pregnancy is the basic guarantee of having a healthy baby, and it is especially important for older couples, who must start paying attention to every little bit of life. Modern women play an increasingly important role in society and are also under pressure from various aspects of society, including work pressure, such as staying up late and eating irregularly, and family pressure, such as bringing up children, doing housework and taking care of the elderly. This strong mental and physical stress can affect the normal secretion of hormones in a woman’s body and inhibit normal ovulation of the ovaries, which in turn affects the normal discharge of the eggs. Therefore, the first thing you need to do to prepare for your second child is to relax, adjust your emotions, and regulate your stress to increase your chances of conception. The first thing you need to do is to take care of your weight. Obesity may not only endanger your health, but also lead to hormonal disorders, such as hyperandrogenism leading to hirsutism or even polycystic ovary syndrome, which affects the function of the ovaries and thus the whole process of ovulation, resulting in the eggs not being discharged normally, which greatly reduces the probability of conception. However, it is not true that the thinner you are, the better. If your body is too thin, it will cause insufficient secretion of follicle stimulating hormone and luteinizing hormone by the pituitary gland, which will reduce the production of eggs by the follicles and even lead to chronic non-ovulation and infertility, and the incidence of anemia, premature birth and fetal growth restriction in women due to low weight also increases significantly. Therefore, it is especially important to maintain a healthy weight and a balanced diet for both the mother and the baby’s development in the womb. Third, avoid “harsh environment” in the modern social environment hidden in many dangerous factors to prepare for pregnancy and pregnant women can not be underestimated, if women are pregnant, need to properly reduce or avoid prolonged exposure to radiation environment. Here, I would like to emphasize that scientific tests have shown that there is no difference between the amount of radiation received by a pregnant woman wearing radiation-protective clothing and a pregnant woman not wearing radiation-protective clothing. In addition, there is an endless variety of decoration materials, containing formaldehyde and other harmful chemical materials, which can increase the probability of developing leukemia and other diseases. Therefore, if you want to “create a child”, it is best not to live in a house that has just been renovated for a short time. The most important concern for senior couples preparing for their second child is their declining fertility. Therefore, in addition to the above-mentioned factors that need attention, the correct evaluation of ovarian reserve function is the key to conception and fertility quality. Ovarian reserve function, also known as ovarian reserve, refers to the potential of the ovaries to produce eggs in quantity and quality, and indirectly reflects the function of the ovaries. The main indicators currently used in clinical practice to assess ovarian reserve are age, basal follicle stimulating hormone (FSH), FSH/LH (luteinizing hormone), basal inhibin B (INHB), basal anti-mullerian hormone (AMH), basal estradiol (E2), clomiphene provocation test (CCCT), FSH ovarian reserve test (EFORT), gonadotropin-releasing hormone agonist (GnRH-a) stimulation test (GAST), basal sinus follicle count, ovarian volume and interstitial ovarian artery blood flow. The good or bad ovarian function directly affects women’s fertility. Therefore, for senior women who have been trying to conceive normally for 3 months without successful conception, it is advisable to go to a regular hospital to have a comprehensive, formal and systematic evaluation of their ovarian function. Folic acid is an important nutrient for embryonic neurodevelopment, and once a woman’s body is deficient, it will affect the neural tube development of the embryo, leading to the birth of anencephalic children, spina bifida, brain bulge and other malformations. The amount of folic acid contained in food in our dietary structure is often not enough to meet the daily needs of pregnant women, so it is important to start taking folic acid supplements at least three months before conception. Of course, senior couples need to pay attention not only to the above points, but also need to do more exercise, change bad habits, quit smoking and drinking, in the psychological and physical fully prepared to welcome the “good pregnancy”.