A four year old child with persistent high fever needs to be treated with appropriate antipyretic methods, such as physical hypothermia and oral medications, depending on the degree of elevation of the child’s temperature. It is also important to treat the cause of the fever. Fever is a common symptom in childhood, for children with fever but body temperature <38.5℃, we can use physical methods to reduce the temperature such as applying warm water to the child's forehead, reducing the amount of clothing worn, and encouraging the child to drink more fluids, and some children's body temperature can drop gradually. For children with body temperature ≥ 38.5 ℃ also need to use antipyretic drugs such as ibuprofen, acetaminophen and other antipyretic treatment under the guidance of a doctor. At the same time, the treatment of the cause of the disease is also very important for the recovery of body temperature. For respiratory infections caused by bacterial infections, antibacterial drugs such as cefaclor and cefdinir should be actively used to fight infection. In case of juvenile idiopathic arthritis and other rheumatoid immune diseases, naproxen, methotrexate, hydroxychloroquine, salazosulfapyridine and other drugs should be used for treatment. In the case of hematological tumor-related diseases such as leukemia, chemotherapy with drugs such as vincristine, Zorubicin, Mentholase, Prednisone, etc., and bone marrow transplantation, etc., if necessary, will be required. All of the above drugs need to be used under doctor's guidance, avoid self-medication. There are many other causes of fever in 4-year-olds, and it is recommended to seek prompt medical attention and be evaluated and treated by a specialist to avoid delays.