Pain behind the heart after drinking alcohol may be caused by alcohol poisoning, sympathetic overexcitation, coronary artery disease and other conditions, which can be treated by drugs. 1. Alcohol intoxication: the patient is intoxicated by alcohol due to large amount of alcohol consumption, which causes alcoholic cardiomyopathy leading to pain behind the heart. It can be treated with drugs such as diazepam injection, nalmefene hydrochloride injection, naloxone hydrochloride sublingual tablets, etc. under doctor’s guidance. 2. Excessive sympathetic nerve excitation: the patient’s sympathetic nerve excitation caused by alcohol stimulation leads to abnormal myocardial electrocardiographic activity, increased cardiac output, resulting in autonomic nerve disorders, leading to pain behind the heart. Oral atenolol tablets, metoprolol tablets, sotalol hydrochloride tablets and other drugs can be used for treatment. 3. Coronary heart disease: under the stimulation of alcohol, coronary heart disease patients, heart load enhancement, triggering hypoxia and myocardial ischemia, resulting in pain behind the heart. Oral aspirin tablets, bisoprolol tablets, metoprolol tablets and other drugs for treatment. Patients with pain behind the heart after drinking alcohol need to go to the hospital for treatment in a timely manner, under the guidance of the doctor to use drugs, follow the doctor’s instructions, so as not to delay the condition.