A squatting knee pain may be caused by degenerative lesions, patellofemoral arthritis, knee trauma and other factors, you should consult a doctor in time to identify the cause and timely treatment. 1. Degenerative lesions: degenerative lesions of the knee joint is a chronic and progressive joint disease. Its pathology is characterized by degeneration and destruction of articular cartilage, sclerosis of the subchondral bone, reactive hyperplasia of the joint margins and subchondral bone, and the formation of bone redundancy. Mostly seen in the middle-aged and elderly people, there will be a squatting knee pain symptoms. 2. Patellofemoral arthritis: it refers to the aseptic inflammation of the joint surface between the patella and the femur, which may cause knee pain when squatting, and may be accompanied by stiffness and weakness of the knee joint. 3. Knee trauma: If the knee joint is injured by collision, strenuous exercise and other traumatic injuries, it will lead to damage to the soft tissues around the knee joint, meniscus and other injuries, which will cause the symptoms of knee pain when squatting, and in severe cases, it can be accompanied by swelling and activity disorders. There are many other causes of knee pain when squatting, so it is recommended that the patient consult a doctor in time to make a clear diagnosis, so as not to delay the condition.