Frequent urination, urinary urgency, urinary distension may be caused by urinary tract infection, urinary stones, tumors, etc. The ineffectiveness of levofloxacin may be due to the development of drug resistance by long-term use, but it may also be due to the incorrect cause of the drug. Levofloxacin is a broad-spectrum antibiotic, targeting gram-negative bacteria such as Escherichia coli and Proteus mirabilis, and has a good antibacterial effect. If it is mycoplasma, chlamydia infection caused by urinary tract infection, prostatitis, the use of levofloxacin may not be very effective. If you take levofloxacin for a long time you may develop drug resistance, and it does not have a better effect on the urinary tract infection of urinary frequency, urinary urgency, urinary distension. In case of urinary tract obstruction caused by urethral stones, tumors and other diseases, it will lead to narrowing of the urethra and frequent urination, urgency and distension. In the case of urethral stones, only using levofloxacin at this time is not effective in improving the symptoms of frequent urination, urinary urgency, and urinary distension. Patients with small stones need to combine captopril, tamsulosin and other lithotripsy drugs; patients with large stones that meet the indications for surgery can use extracorporeal shock wave lithotripsy, endoscopy-assisted lithotripsy and other surgical treatments. The above drugs are for reference only, the specific dosage should follow the doctor’s instructions. Frequent urination, urinary urgency, urinary distension should be timely medical treatment, follow the doctor’s instructions for further examination, with the help of the doctor to clarify the cause, follow the doctor’s instructions for treatment, do not blindly use drugs.