There is a difference in the composition, efficacy and indications of tonifying the center of the body and the ten whole big tonic pills. 1. Differences in drug composition: tonifying the middle and benefiting the qi pill consists of roasted astragalus, codonopsis, roasted licorice, fried atractylodes macrocephala, angelica sinensis, aspergillus, chaihu, and chenpi; shiquan dazhuangwan consists of codonopsis, fried atractylodes macrocephala, poria, roasted licorice, angelica sinensis, chuanxiong rhizome, liquor, peony, ripened diabetes mellifera, roasted astragalus, and cinnamon. 2. Differences in efficacy: tonifying the middle Jiaozhong Yiqi Pill has the efficacy of tonifying the middle Jiaozhong Yiqi (treating deficiency of qi by tonifying the spleen), and elevating yang and lifting the sunken organs (elevating yang qi in the body in order to lift the sunken organs); Shiquan Dajian Pill has the efficacy of warming qi and blood. 3. Different indications: tonic pill is used for diarrhea, prolapse of the anus, yin ting (women’s uterine prolapse and even out of the vaginal opening) caused by weakness of the spleen and stomach, Qi subsidence (spleen and stomach qi deficiency, visceral organs falling and other manifestations), the symptoms of tiredness and fatigue, low food and abdominal distension, loose stool (feces sparse and unshaped) for a long time diarrhea, anus falling or prolapse of the anus, prolapse of the uterus. Shiquan Dazhuang Pill is used for deficiency of qi and blood, pallor, shortness of breath and palpitation (rapid heartbeat, often accompanied by panic), dizziness and spontaneous sweating (involuntary sweating during the day, aggravated by sweating with a slight movement), fatigue and tiredness, lassitude, and heavy menstruation. The adverse reactions and contraindications of both Tonify Zhong Yi Qi Pill and Shiquan Da Mending Pill are not clear. Precautions are avoid indigestible food; should not be taken by patients with cold and fever. Chinese medicines or proprietary Chinese medicines need to be used under the guidance of a Chinese doctor to identify the evidence, and individuals should not use them blindly to avoid adverse consequences.