Pain in the middle of the lower abdomen is usually due to the following diseases: prostate disease, bladder disease, uterine disease, rectal disease and so on. 1. Prostate disease: If you are an older male, consider whether prostatitis exists. The prostate gland is located in the middle of the lower abdomen, and when inflammation occurs, it may cause pain in the lower abdomen. 2. Bladder disease: pain in the middle of the abdomen may also be caused by urinary tract infection cystitis, can be clearly diagnosed through urine and blood tests. 3. Uterine diseases: If you are a woman, consider whether there are gynecological diseases, including uterine fibroids, ovarian cysts and other diseases causing pain in the middle of the abdomen. 4. Rectal diseases: including enteritis or diseases caused by bacterial infections in the intestines, which can be diagnosed through blood tests and temperature measurement. The pain in the middle of the lower abdomen may be due to other reasons, you need to go to the hospital, improve the relevant examination, clear the cause of the disease and then carry out targeted treatment.