Taking sodium bicarbonate does not have the effect of lowering uric acid, but it has the effect of promoting the excretion of uric acid from the body, because sodium bicarbonate is an alkaline drug that has the effect of alkalizing urine, and the increase of pH value in urine is conducive to the dissolution of uric acid in urine, so it can help the excretion of uric acid from the body. Commonly used drugs with uric acid lowering effect are allopurinol, febuxostat and benzbromarone, the first two of which are drugs that inhibit the production of uric acid, while benzbromarone promotes the excretion of uric acid. Different drugs have different indications and contraindications. Allopurinol, for example, is not recommended for patients with severe hepatic or renal impairment and for patients with allergic reactions to allopurinol, as it may induce fatal exfoliative dermatitis. Allopurinol should be used from small doses and also in combination with non-steroidal anti-inflammatory drugs or colchicine to prevent acute gouty arthritis attacks.