Heartburn in the middle of the night refers to a burning sensation in the lower chest and upper abdomen, which is accompanied by acid reflux in the stomach. There are many reasons for excessive secretion of stomach acid, such as over-eating, eating too fast, eating spicy and stimulating, excessive stress in work life, disorder in work and rest, or drinking milk and honey on an empty stomach, which have foods that stimulate the secretion of stomach acid, may cause heartburn. When there are acute and chronic gastroenteritis, gastric ulcer, bile reflux gastritis, reflux esophagitis and other digestive system diseases, it may also cause abnormal secretion of gastric acid or reflux situation, which may cause heartburn. It is advisable for patients with heartburn in the middle of the night to go to the hospital for a clear diagnosis and timely intervention and treatment.