Septic cardiomyopathy refers to the myocardial lesions that occur secondary to the aggravation of the primary disease when severe infection, severe pancreatitis, or sepsis occurs, and even severe arrhythmias, heart failure, and sudden cardiac death. Patients suffering from this disease may not have the basis of myocardial disease originally, but first occurred major trauma or infection secondary, with the onset of critical illness and later appeared, with the cure of critical illness and relief or even cured. Clinical features include elevated cardiac enzymes, characteristic changes in the electrocardiogram, and alterations in hemodynamics and myocardial mechanics, but the lack of characteristic clinical manifestations in the majority of patients makes the condition easily overlooked. Severe patients often develop malignant arrhythmias, hypotension, heart failure, and even death. Septic cardiomyopathy is now an important cause of death in many patients with severe infections, and its prevention and treatment are important.