What medication to take for yellow fluid from the ear needs to be tailored to the cause, commonly otitis externa and otitis media, otitis externa usually choose anti-infective drugs, otitis media usually choose antibiotic treatment. 1. Otitis externa: Otitis externa can be caused by fungal infections as well as bacterial infections will have the symptom of yellow fluid. Anti-infective treatment is usually chosen, and ciprofloxacin and mycotoxin can be chosen. 2. Otitis media: Otitis media can cause pain in the ear area, and there will be discharge, sometimes yellow fluid, sometimes pus discharge. Antibiotics should be used under medical supervision to control the infection, such as erythromycin and cefazoxime. If there is ear pain as well as fever, acetaminophen or ibuprofen can be chosen. Yellow fluid from the ear has many causes, and it is recommended not to ignore it and go to a regular hospital for timely consultation and standardized treatment.