Both Xiao Li, a young man from the suburbs of Beijing, and Xiao Yang, a girl from Liaoning, were seen at a local hospital, where a CT chest examination revealed “a huge mass in the anterior mediastinum, pushing and compressing the superior vena cava, and displacing the mediastinum to the left.” Due to the huge mass in the anterior mediastinum, which wraps the largest vein in the body, the risk of surgery is too great, and several tertiary hospitals consider it inoperable. Not only that, they were also accompanied by weakness of limbs, difficulty in swallowing, and even difficulty in breathing. Although the diagnosis was clear: invasive thymoma, myasthenia gravis, the tumor wrapped around the superior vena cava and the anomalous vein, which made surgery too difficult, and the possibility of postoperative myasthenia gravis, made these hospitals refuse to treat these two patients. It was through various channels that we heard about the Capital Medical University Research Center for Myasthenia Gravis in front of Beijing Tongren Hospital and saw a newspaper report about Yu Lei’s treatment of a huge tumor in the thoracic cavity in the Department of Thoracic Surgery, so we raised money to come to Beijing Tongren Hospital to treat the “incurable disease”. After the patient was hospitalized, we arranged further systematic and comprehensive examinations for him, and the enhanced CT of the chest showed that “the mass in the anterior mediastinum was not only huge, but also partially encapsulated the superior vena cava and the left unnamed vein”. The biggest risk of the operation was the rupture of the superior vena cava and the left ringlet vein, and intraoperative hemorrhage. Although some doctors wished to ask more famous specialists in Beijing to consult with them, they put off with excuses. In fact, these tumors are often insensitive to radiotherapy and chemotherapy, and without surgery the patient would have to wait for death. After carefully studying all the examinations, we thought: this is a rare clinical case and the operation is very risky, we as medical workers in the capital should dare to take the risk and relieve the pain of the patients nationwide. With meticulous preparation, we did our homework on surgical details and operations to avoid fatal hemorrhage during the operation, and it is still guaranteed that this operation will be completed and the patient will be fully cured. Before the surgery, in order to evaluate the patient more fully and accurately, Dr. Yu Lei had an extensive exchange of opinions with other thoracic surgeons after all the examinations were completed. Based on their own experience, many experts offered valuable insights, including: (1) the possibility of right lung infiltration, (2) how to avoid intraoperative hemorrhage if the tumor had invaded large blood vessels, and (3) how to position the body to fully reveal the anterior mediastinum. These insights later proved to be a solid theoretical foundation for the success of the operation. According to the opinions of the experts in thoracic surgery, two patients were operated by Dr. Yu Lei, deputy chief of thoracic surgery of Beijing Tongren Hospital, in the operating room of Beijing Tongren Hospital. The surgery removed the huge tumor in the anterior mediastinum and removed part of the lung lobes infiltrated by the tumor. The most difficult part of the surgery was that the tumor had to be completely removed by dissecting the superior vena cava and the left innominate vein, and then the thymus and the displaced thymus in the anterior mediastinum had to be completely removed in order to reduce or avoid the postoperative myasthenia crisis. After the surgery, while controlling the amount of rehydration fluid and infusing colloid fluid, he was transferred to the ICU intensive care unit with tracheal intubation for monitoring and ventilator-assisted ventilation. The tracheal intubation was removed on the 3rd-5th postoperative days and the patient was transferred from the ICU to the general thoracic surgery ward. At this time, the patient’s parents were very excited and said, “It was Dr. Yu Lei and his team from the Thoracic Surgery Department of Beijing Tongren Hospital who gave our son a second life, and they made our family reunited again”. This is the real meaning of establishing the Myasthenia Gravis Research Center of Capital Medical University: to enable patients suffering from thymoma and/or myasthenia gravis to find hope for their lives, to get rid of the disease and to have a new life.