Anti-sperm antibodies are antibodies that a woman produces against sperm because of the presence of proteins on the surface of the sperm. When the antibody binds to the sperm, it destroys the sperm so that it can’t continue to search for an egg to form a fertilized egg, resulting in an inability to conceive. It initiates the killing of the sperm as it enters and can cause infertility. In the presence of antisperm antibodies, usually the male sperm and female ovulation are normal, but the sperm and egg cannot meet. This is a less common manifestation of infertility and may be due to autoimmune changes in the woman’s body rather than disease. While a woman is fine when she is pregnant with her first child, the increase in antibodies after the second or third child will affect the meeting of sperm and egg, making it difficult to form a good quality or viable fertilized egg, resulting in infertility. Therefore, when antisperm antibodies are produced, blocking treatment should be carried out so that the sperm and egg cannot meet and the antisperm antibodies in the woman’s body will be reduced naturally. The above treatments will reduce the antisperm antibodies so that there is a chance for the sperm to combine with the egg when it enters in the future.