Anti-epileptic treatment is still the main treatment with anti-epileptic drugs. After antiepileptic drug treatment, about 70% to 80% of patients have their seizure symptoms controlled, but there are still 20% to 30% of patients who cannot be controlled and become refractory to epilepsy. Some of the patients with refractory epilepsy can be controlled with surgical treatment. Anti-epileptic drug therapy should follow the following principles: 1. Early treatment after diagnosis. Generally 2 seizures should be started with medication. 2. Rational selection of antiepileptic drugs. The choice of drugs should be based on the type of seizure or epilepsy syndrome. 3, try to monotherapy, only when monotherapy is really ineffective, then consider reasonable combination therapy. 4. Monitor the necessary therapeutic drugs and adjust the dose according to pharmacokinetic parameters and clinical effects. 5.Simplify the method of drug administration. Administer the drug according to the drug half-life and allocate the dosing interval. 6.Regular dosing. Change or discontinue medication reasonably, avoid self-adjustment, discontinuation and drug abuse. 7.Follow up regularly. Pay attention to adverse reactions and give the necessary psychological support. 8. Rational application of new antiepileptic drugs. 9. If relapse occurs after drug discontinuation, the original regimen can be resumed and most of them are still effective. 10. Emphasize that the goal of treatment is to enable the child to have the best quality of life. 11. The principle of individualization of treatment is always highlighted.