Colonic mucosal congestion and edema may be caused by colitis, colitis is divided into inflammatory bowel disease, infectious colitis, ischemic colitis, pseudomembranous colitis, etc. Doctors will decide on the treatment according to the specific situation of the patient, and the treatment is mainly drug therapy. Colitis is an inflammatory lesion of the colon caused by a variety of reasons, which can be caused by bacteria, protozoa and other organisms. Patients usually have diarrhea, abdominal pain, mucus stools and pus and blood stools, acute and severe, constipation and other manifestations, often accompanied by lethargy and fatigue, etc., and more recurring episodes. 1. Inflammatory bowel disease: aminosalicylic acid preparations are the main drugs for the treatment of inflammatory bowel disease, including mesalazine, olanzapine and salazosulfapyridine. 2. Infectious colitis: Doctors will determine the infectious agent according to the patient’s feces as well as the results of drug sensitivity test, and choose appropriate antibiotics for treatment. Such as bacterial dysentery with quinolones, such as ciprofloxacin; amoebic dysentery with nitroimidazoles, such as metronidazole and diclofenac. 3. Ischemic colitis: moderate to severe patients can apply broad-spectrum antibiotic therapy. 4. Pseudomembranous colitis: the relevant pathogenic antibiotics should be discontinued as early as possible, and severe cases should be treated with antibiotics against Clostridium difficile, including metronidazole and vancomycin. Patients should follow the doctor’s instructions, do not blindly use their own medication, so as not to delay the condition or cause adverse reactions.