If the catheter of PICC is blocked, repeated suctioning with sodium heparin can be applied, which usually serves to open the catheter, and attention should be paid to daily care. The catheter should be sealed promptly after the administration of the drug, and saline diluted with sodium heparin is also always chosen. Avoid strenuous activities of the affected limb or cause local catheter pressure, which will also affect the drug delivery, or even manifest as blockage or not fluent performance. Because PICC catheterization is mostly used for intravenous chemotherapy or advanced consumption of patients, patients with peripheral venous collapse, so attention should be paid to care, especially to avoid infection, because after all, it is a foreign body, easy to secondary infection, if there is an unknown cause of fever, it should be actively retired, and it must be retained for bacteriological culture.