Patient: Description of the condition (onset time, main symptoms, hospital visited, etc.): Hello, doctor. My father is 72 years old, has a history of smoking, emphysema, cough, sputum in the morning, chest tightness. High blood pressure, no heart disease. Four years ago, he was given the following medications and doses: paracetamol 60 tablets, aminophylline 60 tablets, asthma 80 tablets, cough medicine 80 tablets, prednisone 60 tablets, cotrimoxazole 30 tablets, lisdexamfetamine 80 tablets, licorice 90 tablets. Mix them into a fine powder, divided into 60 packets, 1 packet per day. Do not eat chest tightness. Take it and get well. Now the whole body weakness. Drowsiness. This formula, eaten for 4 years. What are the side effects of taking it for a long time? What is the alternative medicine? What are the treatment options? Thank you, Hospital Respiratory Department: Hello, it is best not to use prednisone for a long time, because systemic hormones have great side effects, such as increased blood sugar, obesity and osteoporosis. Therefore, it is recommended that pulmonary function tests should be conducted and hormones should not be used if the patient has emphysema alone, but if the patient has more than emphysema and has hypoventilation, then surface hormones can be applied instead of systemic hormones.