Patients with emphysema eventually die in a more difficult way. Patients with emphysema may have more severe respiratory symptoms as well as systemic symptoms at the time of death. Coma may occur during this time due to hypercapnia, carbon dioxide retention, and eventually death. Emphysema is a respiratory disease caused by a variety of diseases, including bronchial asthma, in which the patient’s alveoli are damaged, and at the same time the efficiency of pulmonary ventilation and pulmonary air exchange is dramatically reduced. At the same time, emphysema can lead to pulmonary hypertension, which can increase the load on the heart and lead to pulmonary heart disease. Patients with advanced combined heart disease may exhibit symptoms of oxygen deprivation such as breath-holding, palpitations, and weakness. In addition, carbon dioxide retention is severe in patients with advanced emphysema, and excessive carbon dioxide can enter the blood-brain barrier, causing patients to suffer from mental abnormalities such as confusion and coma, as well as respiratory acidosis. In severe cases, the coagulation function of the patient’s body may become impaired, and even serious adverse consequences such as bleeding of organs and stress ulcers may occur. In summary, it is more difficult for patients with emphysema to die in the end. It is recommended to actively receive medication when the disease is mild, and pay attention to good living and eating habits. If the symptoms worsen, consult your doctor to clarify the cause and give treatment in time to prevent life-threatening symptoms of emphysema from worsening.