A dense blister on the hand needs to be treated according to its cause, such as allergic factors, herpes zoster, sweat herpes, etc., after a clear diagnosis, choose general treatment or drug treatment. 1. Allergic factors: contact with allergens on the hands, may be localized dermatitis attacks, resulting in a dense blisters on the hands of the phenomenon. Treatment needs to avoid allergens, and then follow the doctor’s instructions to take antihistamines, such as loratadine, cetirizine, while with the use of topical fusidic acid cream, dinexidine cream use. 2. Herpes zoster: a dense blister on the hand may be infected with chickenpox – herpes zoster virus, the need to use antiviral drugs, such as topical acyclovir ointment, ganciclovir ointment, oral acyclovir medication, and at the same time, to avoid scratching the hand, so as not to lead to local infection. 3. Sweat herpes: Sweat herpes belongs to a type of eczema, which can lead to a dense blister on the hand. The treatment can use Hasinide cream, Halomethasone cream, severe cases can be combined with the compound glycyrrhizin capsule treatment. There are many reasons for a dense blister on the hand, after the symptoms, it is recommended to go to the hospital in a timely manner to improve the examination, under the guidance of the doctor to take standardized treatment, can not be private treatment, so as not to lead to adverse consequences.