The common causes of gastrointestinal bleeding in adolescents are peptic ulcer, cirrhosis, rupture and bleeding of esophagogastric varices, cardia mucous membrane tear, etc., should be fasting and water, applying acid-suppressing drugs such as omeprazole, replenishment of fluids and transfusion to maintain the stability of the blood circulation, and endoscopic hemostasis treatment when necessary. 1. Peptic ulcer: the most common cause of gastrointestinal bleeding, should be fasting water, bleeding volume of blood circulation instability should be given to rehydration and expansion of blood transfusion therapy, the application of omeprazole, rabeprazole acid suppression, conservative treatment is not effective to endoscopic hemostasis treatment. 2.Cirrhosis esophagogastric fundus varices rupture bleeding: should be fasting water, bleeding volume should be emergency rehydration and expansion of blood transfusion therapy, the application of omeprazole acid suppression, growth inhibitors to reduce portal pressure, thrombin lyophilisate powder hemostasis therapy, endoscopic hemostasis or interventional therapy, if necessary. 3. cardia mucosa tear: should be fasting water, bleeding large amount of people to rehydration transfusion treatment, the application of omeprazole acid suppression, thrombin lyophilisate powder, Yunnan Baiyao hemostasis, if necessary, endoscopic treatment. If upper gastrointestinal bleeding occurs, it is recommended to immediately seek medical attention, standardized treatment and medication under the guidance of a doctor.