Diarrhea with blood and mucus is considered to be related to many diseases, and the specific drugs to be taken should be tailored to the condition and the cause. If it is a simple acute gastroenteritis, because the diarrhea is more serious, stimulating the intestinal mucosa, resulting in localized blood oozing from the intestinal mucosa, mucus and with blood can apply appropriate mucosal protection, antidiarrheal drugs and anti-infective drugs, such as montelukast, diphenoxylate, bifidobacterium, norfloxacin, etc.. In case of ulcerative colitis or Crohn’s disease, it is possible that targeted medications are needed for treatment, such as salazosulfapyridine, mesalazine, and olsalazine. If the blood or mucus is more severe, hormonal drugs such as prednisone and dexamethasone may also be used. In addition, if a gastrointestinal tumor is suspected, gastroscopy with colonoscopy and related tests may be required to rule out other diseases.