The reasons for the simultaneous increase of creatinine and uric acid usually indicate the decline of kidney metabolic function, which is generally considered to include polycystic kidney, chronic kidney disease, hypertensive nephropathy, and obesity-associated glomerulonephropathy. 1. Polycystic kidney: it is common that patients with polycystic kidney have high blood pressure which cannot be controlled or consume a lot of high purine food, which may cause the increase of blood creatinine and uric acid. 2. Chronic kidney disease: for example, chronic glomerulonephritis, which is easy to cause kidney damage, resulting in decreased renal filtration rate, causing increased blood creatinine, and if the condition is more serious, resulting in renal failure, it will also cause uric acid accumulation, causing high uric acid. 3. Hypertensive nephropathy: patients often have increased urinary protein as well as increased blood creatinine, accompanied by increased uric acid. 4. Obesity-related glomerulopathy: especially obesity-related focal segmental sclerosis patients, may be accompanied by abnormal glucose metabolism, which can also cause blood creatinine and uric acid increase. It is recommended that patients go to the hospital in time, complete the relevant examinations under the guidance of the doctor, clarify the causes, and actively treat to avoid the progression of the disease.