Surgical procedures for descending duodenal mesenchymal tumor include duodenal wedge resection, partial duodenectomy, segmental duodenectomy, and total duodenectomy with pancreas preservation. 1. Duodenal wedge resection: mesenchymal tumors located in the non-papillary region with a diameter of 1-2 cm, or mesenchymal tumors with a diameter of ≤1 cm at the mesenteric margin of the duodenum. If the tumor is clearly demarcated from the pancreas on imaging, duodenal wedge resection is feasible. 2. Partial duodenectomy: direct closure of the papillary area after tumor resection may affect the function of duodenal papilla, partial duodenectomy is feasible. 3. Segmental duodenectomy: for large mesenchymal tumors located in the non-papillary area, segmental duodenectomy should be performed according to the location of mesenchymal tumor, including resection of the first to the proximal end of the second segment of duodenum and resection of the second and third segment of the duodenum, and resection of the second and third segment of the duodenum, and resection of the fourth segment of the duodenum. 4. Total duodenectomy with preservation of the pancreas: for larger mesenchymal tumors located in the papillary region and the tumor does not invade the pancreas, total duodenectomy with preservation of the pancreas can be used. For mesenchymal tumor of descending part of duodenum, one should go to the hospital for treatment in time, and choose the appropriate surgery for treatment under the guidance of doctor according to the specific conditions of the disease.