Diarrhea and nosebleeds are associated with coagulation disorders, diarrhea, indigestion, and nasal mucosa erosion. Diarrhea and nosebleeds are not the same disease. If both conditions occur at the same time, it is mainly considered to be related to the patient’s coagulation disorder. In some patients, diarrhea accompanied by tarry stools is considered to be caused by gastrointestinal bleeding; nosebleeds are considered to be a coagulation disorder, which can also lead to multi-organ bleeding. In addition, common diarrhea accompanied by nosebleeds is considered to be caused by two diseases. Patients may have diarrhea due to enteritis or dyspepsia, where the intake of irritating food leads to rapid peristalsis of the gastrointestinal tract. Nasal bleeding is mainly considered to be related to infection of the upper respiratory tract, where the human body is on fire leading to nasal mucosa erosion. The cause of the disease can be understood by promptly going to the hospital for routine stool, routine blood and rhinoscopy.