Low pH 5.0 can be treated with medication or surgery depending on the secretions, such as urine and esophageal fluid, respectively. 1. Urine: low pH in urine may be due to physiologic factors, such as consumption of excessively acidic foods, and dietary adjustments are recommended. Pathological factors are commonly found in metabolic diseases, such as diabetic ketoacidosis requires rehydration, intravenous insulin to eliminate ketone bodies. For hyperuricemia, oral uric acid-lowering drugs such as benzbromarone and sodium bicarbonate are needed. 2. Esophageal fluid: if there is a low pH in the esophagus, there may be reflux of gastric juice, causing reflux esophagitis, and it is necessary to follow the doctor’s instructions to take acid-suppressing drugs such as omeprazole, rabeprazole, etc., and to promote gastrointestinal dynamics of drugs such as domperidone, mosapride, etc.. If accompanied by esophageal stenosis, obstruction, cancerous lesions may require surgical treatment. It is recommended to go to the hospital in time to clarify the cause of the disease, and according to the cause of targeted treatment.