Reishi can be taken during chemotherapy because the substance has relatively certain medicinal value and can be taken by many patients with malignant tumors during treatment, which has a certain role in improving immunity and has relatively few side effects. Patients with intravenous chemotherapy are also prone to gastrointestinal reactions, bone marrow suppression, and even immune deficiency during treatment, so they can take Ganoderma lucidum. At the same time, antiemetic, gastrointestinal mucous membrane protection, liver function and kidney function protection drugs should be routinely given during the treatment period to prevent related complications. Patients should also be advised to drink more water during treatment to speed up drug metabolism. In addition, light foods should be used to avoid adverse gastrointestinal reactions that may aggravate the patient’s pain.