H. pylori is contagious and if one spouse has H. pylori infection, the other spouse should also be tested for H. pylori. The first case, if the other person also has H. pylori infection, both of them can be treated with H. pylori clearance at the same time, mainly including an acid suppressant, such as omeprazole, pantoprazole, rabeprazole, lansoprazole, etc., plus two antibiotics, chosen from the following, such as amoxicillin, clarithromycin, metronidazole, levofloxacin, etc. . In the second case, if the other party is not infected, a meal sharing is required and then the infected person is treated according to the above protocol.