Children with HFMD will have a fever. HFMD is an acute febrile rash infectious disease caused by enteroviruses, and is most common in children under five years of age. Symptoms that appear in the early stages of the disease include low-grade fever, drowsiness, headache, cough, runny nose, and loss of appetite, which are easily confused with colds. After 1-2 days of fever, many red papules with small blisters in the center, such as the size of a grain of rice or a pea, appear on the mucous membranes of the mouth, the palms of the hands, the feet, and the buttocks. If the oral herpes breaks, the child may resist eating and breastfeeding and develop symptoms of crying due to pain. The duration of HFMD is usually 1-2 weeks and the prognosis is good. A few severe cases may be complicated by viral encephalitis, myocarditis, pneumonia, or involve the nervous system and die. Because there is no specific anti-viral drugs, parents are advised to vaccinate their children against HFMD at the appropriate age, which can effectively prevent children from developing HFMD.