Low pepsin 1 may be caused by dietary factors, gastritis, gastric ulcer, Helicobacter pylori infection and so on. 1. Dietary factors: if you often eat spicy and stimulating food or too sweet food, it will often cause some stimulation to the gastric mucosa, resulting in increased secretion of gastric acid, which will cause low pepsinogen 1. 2. Gastritis, gastric ulcer: mainly because of the excessive secretion of gastric acid, will cause some stimulation of the stomach wall, resulting in damage to the gastric mucosa, which causes the symptoms are often accompanied by stomach acid, heartburn, stomach pain and other symptoms. 3. Helicobacter pylori infection: If the stomach is infected with Helicobacter pylori, it will often lead to bacterial imbalance and abnormal secretion of gastric acid, which will lead to low pepsinogen 1 and symptoms such as early satiety, belching (hiccups), bloating, acid reflux and bad breath. If low pepsinogen 1 is caused by a disease, it is important to actively consult and cooperate with your doctor for treatment.