After the anticardiolipin antibodies have turned negative, there is a possibility that they will turn positive again and a relapse will occur. There are many kinds of positive antiphospholipid antibodies in patients with antiphospholipid syndrome, including anticardiolipin antibody and lupus anticoagulant, etc., which can put the body in a hypercoagulable state, mainly manifested as arteriovenous thrombosis, thrombocytopenia, etc., and even spontaneous abortion. Treatment includes anti-platelet aggregation such as drug aspirin, anticoagulant therapy such as warfarin, etc., and promotion of fibrinolytic streptokinase. Antiphospholipid syndrome after treatment, the emergence of antiphospholipid antibodies turn negative, but also should be regularly rechecked, because the control is not good may also appear to turn positive again. It is important to note that patients with antiphospholipid syndrome can minimize the adverse effects of the disease through “early detection, early diagnosis and early treatment”. Patients are advised to have regular checkups, and the above medications should be used according to the doctor’s instructions, and should not be used on their own in order to avoid adverse effects.