Whether creatinine will fall to normal after stopping Irbesartan mainly depends on whether the patient’s kidneys have been irreversibly damaged organically. Irbesartan is an angiotensin II receptor antagonist, which is commonly used in the treatment of hypertension in clinical practice. Some patients may experience kidney damage after using Irbesartan, which can be manifested as an increase in blood creatinine. If the patient’s kidney damage is mild and there is no organic damage, the creatinine can mostly return to normal after stopping the drug. If the patient’s kidney damage is more serious, with organic damage, or there are other reasons such as infection, trauma and other causes of kidney damage, usually creatinine can not return to normal after stopping the drug. In addition, when Irbesartan is applied to patients with renal impairment, regular monitoring of serum potassium and creatinine is recommended. Patients taking Irbesartan orally should not stop taking the drug on their own, and it is recommended to go to regular hospitals for consultation, and be judged by specialists in combination with the patient’s specific situation.