Usually there is a small fluctuation in PSA if prostate cancer is operated on. Typically, postoperative follow-up consists of an outpatient history, anal examination, and prostate-specific antigen (PSA) monitoring. This is done every three months for one year, every three to six months for the second year, every six to twelve months for the third year, and at any time during this period, depending on the individual’s circumstances. Normally, a prostate-specific antigen (PSA) level after prostatectomy should be less than 0.2 ng/mL, and if it is greater than that, it should be considered a recurrence of the cancer or a residual tumor. Prostate-specific antigen (PSA) is a specific protein secreted by the epithelial tissue of the prostate gland. Prostate-related diseases, including benign prostatic hypertrophy, inflammation of the prostate gland, recent cystourethroscopy, catheter insertion, and prostate cancer, can cause PSA to rise.